Recurrent Drug-Induced Insulin Autoimmune Syndrome in a Patient with Premature Ovarian Failure

European Journal of Inflammation

Letter to the Editor

R. Krysiak¹  B. Okopien² 

[1] Robert Krysiak, MD, PhD, Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland, Tel./Fax [phone], e-mail: ;Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland;

关键词: insulin autoimmune syndrome;    premature ovarian failure;    autoimmune polyglandular syndromes;    diagnosis and treatment;   

DOI  :  10.1177/1721727X1201000115

 received in 2011-05-05, accepted in 2011-11-30,  发布年份 2012

来源: Sage Journals

【 摘 要 】

Insulin autoimmune syndrome (IAS) is characterized by hypoglycemic attacks, very high insulin levels and the presence of circulating autoantibodies to insulin in patients who have not been treated with exogenous insulin. Approximately half of patients with insulin autoimmune syndrome have a medication history preceding hypoglycemic events. We present the case of a young woman with premature ovarian failure who developed IAS initially after treatment with methimazole and several years later after captopril, and because of coexistent premature ovarian failure was classified as having autoimmune polyglandular syndrome (APS) type 3. Termination of methimazole and Captopril treatment resulted in the disappearance of hypoglycemic episodes. We discuss diagnostic and treatment dilemmas associated with discovering and management of IAS and APS in this patient.

【 授权许可】

Unknown   
© 2012 SAGE Publications