Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?

European Journal of Inflammation

Original Article

R. Kazancioglu¹  M. Koldas²  Y. Doventas²  S. Karadag³  Z. Aydin³  A. Sumnu³  S. Uzun³  S. Ozturk³  M. Gursu³ 

[1] Bezmialem Vakif University, Medical Faculty, Department of Nephrology, Istanbul, Turkey;Haseki Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey;Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey;

关键词: atherosclerosis;    endothelial dysfunction;    inflammation;    pentraxin-3;    peritoneal dialysis;   

DOI  :  10.1177/1721727X1201000305

 received in 2012-04-22, accepted in 2012-07-25,  发布年份 2012

来源: Sage Journals

【 摘 要 】

Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7±12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16±2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.

【 授权许可】

Unknown   
© 2012 SAGE Publications