Triggers for Autism: Genetic and Environmental Factors

Journal of Central Nervous System Disease

Article

Norio Mori¹  Takayuki Manabe²  Keiko Iwata³  Hideo Matsuzaki³ 

[1] Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan.;Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan.;Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.;

关键词: autism;    prevalence;    susceptibility genes;    environmental factors;    animal models;   

DOI  :  10.4137/JCNSD.S9058

来源: Sage Journals

【 摘 要 】

This report reviews the research on the factors that cause autism. In several studies, these factors have been verified by reproducing them in autistic animal models. Clinical research has demonstrated that genetic and environmental factors play a major role in the development of autism. However, most cases are idiopathic, and no single factor can explain the trends in the pathology and prevalence of autism. At the time of this writing, autism is viewed more as a multi-factorial disorder. However, the existence of an unknown factor that may be common in all autistic cases cannot be ruled out. It is hoped that future biological studies of autism will help construct a new theory that can interpret the pathology of autism in a coherent manner. To achieve this, large-scale epidemiological research is essential.

【 授权许可】

CC BY-NC   
© 2012 SAGE Publications.