期刊论文详细信息
Cell Transplantation
A Novel Strategy to Enhance Mesenchymal Stem Cell Migration Capacity and Promote Tissue Repair in an Injury Specific Fashion
Article
E. Squarcina1  A. S. Fabricio2  M. Morigi3  V. Benedetti3  A. Benigni3  E. Gagliardini3  C. Xinaris3  B. Imberti3  G. Remuzzi4 
[1] Istituto Oncologico Veneto (IOV)-IRCCS, Padova, Italy;Regional Center for Biomarkers-ABO Foundation, Venice, Italy;“Mario Negri” Institute for Pharmacological Research, Bergamo, Italy;“Mario Negri” Institute for Pharmacological Research, Bergamo, Italy;Unit of Nephrology and Dialysis, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy;
关键词: Mesenchymal stem cells (MSCs);    Migration;    Insulin-like growth factor-1 (IGF-1);    Acute kidney injury (AKI);    Kidney repair;   
DOI  :  10.3727/096368912X653246
 received in 2011-01-26, accepted in 2012-04-30,  发布年份 2013
来源: Sage Journals
PDF
【 摘 要 】

Mesenchymal stem cells (MSCs) of bone marrow origin appear to be an attractive candidate for cell-based therapies. However, the major barrier to the effective implementation of MSC-based therapies is the lack of specific homing of exogenously infused cells and overall the inability to drive them to the diseased or damaged tissue. In order to circumvent these limitations, we developed a preconditioning strategy to optimize MSC migration efficiency and potentiate their beneficial effect at the site of injury. Initially, we screened different molecules by using an in vitro injury–migration setting, and subsequently, we evaluated the effectiveness of the different strategies in mice with acute kidney injury (AKI). Our results showed that preconditioning of MSCs with IGF-1 before infusion improved cell migration capacity and restored normal renal function after AKI. The present study demonstrates that promoting migration of MSCs could increase their therapeutic potential and indicates a new therapeutic paradigm for organ repair.

【 授权许可】

Unknown   
© 2013 Cognizant Comm. Corp.

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Table 2 44KB Table download
Table 2 68KB Table download
Table 3 53KB Table download
Table 4 131KB Table download
Figure 10. 744KB Image download
Table 5 90KB Table download
Figure 1 27KB Image download
Figure 2 33KB Image download
Figure 11. 860KB Image download
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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
  • [27]
  • [28]
  • [29]
  • [30]
  • [31]
  • [32]
  • [33]
  • [34]
  • [35]
  • [36]
  • [37]
  • [38]
  • [39]
  • [40]
  • [41]
  • [42]
  • [43]
  • [44]
  • [45]
  • [46]
  • [47]
  • [48]
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