Pleomorphic Invasive Lobular Carcinoma of the Breast With Extracellular Mucin and HER2 Amplification

Breast Cancer: Basic and Clinical Research

Case Report

Johann D. Hertel¹  Siobhan M. O’Connor¹  Matthew J Burky¹  Benjamin C Calhoun²  Emily M Ray³  David W Ollila⁴ 

[1]Anatomic Pathology, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA

[2]Anatomic Pathology, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA

[3]Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA

[4]Division of Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA

[5]Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA

[6]Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA

[7]Division of Surgical Oncology, Department of Surgery, University of North Carolina, Chapel Hill, NC, USA

关键词: Pleomorphic;    lobular;    invasive;    HER2;    breast;    diagnosis;    pathology;    surgery;   

DOI  :  10.1177/1178223420976383

 received in 2020-10-23, accepted in 2020-10-30,  发布年份 2020

来源: Sage Journals

【 摘 要 】

Invasive lobular carcinoma with extracellular mucin is an uncommon pattern of invasive breast carcinoma. The 5th Edition of the World Health Organization Classification of Breast Tumors states that it is unknown whether these tumors are a subtype of mucinous carcinoma or invasive lobular carcinoma. Invasive lobular carcinoma with extracellular mucin frequently presents as a palpable mass and may be more likely to be grade 2 to 3 and HER2-positive than classic invasive lobular carcinoma. This case of pleomorphic invasive lobular carcinoma with extracellular mucin was detected by imaging only and was HER2-amplified, suggesting that a subset of these tumors may be clinically occult with an aggressive phenotype. Invasive lobular carcinoma with extracellular mucin is infrequently encountered and awareness of this entity is helpful in avoiding misdiagnosis.

【 授权许可】

CC BY-NC   
© The Author(s) 2020

【 图 表 】

Graph 3.