Metabolic Modifications in HIV-Infected Women

European Journal of Inflammation

Virology

R. Paganelli¹  M.R. Manigrasso²  F. Capani²  J. Vecchiet³  F. Travasi⁴  E. Di Ilio⁴  K. Falasca⁴  M.T. Guagnano⁴  P. Zingariello⁴  M. Dalessandro⁴  E. Pizzigallo⁴ 

[1] Allergy and Clinical Immunology, Department of Medicine and Sciences of Aging University “G. d'Annunzio”, Chieti, Italy;Internal Medicine, Department of Medicine and Sciences of Aging University “G. d'Annunzio”, Chieti, Italy;Prof. Jacopo Vecchiet, Dept. of Medicine and Sciences of Aging, Clinic of Infectious Diseases, University “G.d'Annunzio”, Via dei Vestini, 66100 Chieti, Italy, Tel. [phone]; Fax [phone], e-mail ;Sections of Infectious Diseases, Department of Medicine and Sciences of Aging University “G. d'Annunzio”, Chieti, Italy;

关键词: human immunodeficiency virus;    antiretroviral therapy;    metabolic modifications;    leptin;    women;   

DOI  :  10.1177/1721727X0400200106

 received in 2003-10-29, accepted in 2004-01-09,  发布年份 2004

来源: Sage Journals

【 摘 要 】

To assess metabolic alterations and/or abnormal fat distribution in Human Immunodeficiency Virus (HIV)-infected women undergoing Highly Active Antiretroviral Therapy (HAART), a case-control study was carried out in a population of twenty-two HIV-infected, normal weight, non-diabetic, normotensive women. Twenty-five healthy non infected subjects matched for sex, age and Body Mass Index (BMI) were also included as a control group. Blood samples were collected for leptin and insulin measurements. Fasting glucose, triglycerides, total cholesterol and HDL-cholesterol were also measured. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR). Body fat distribution was evaluated using waist-to-hip ratio (WHR), Bioelectric Impedance Analysis (BIA) and abdominal CT-scan. Immunologic and virologic parameters included CD4- and CD8-T cell counts and HIV-RNA levels. HIV-infected patients showed higher levels of total cholesterol, LDL-cholesterol and triglycerides (P<0.05), higher fasting insulin and HOMA-IR (P<0.001), lower levels of HDL-cholesterol (P<0.001) and serum leptin (P<0.001) than the control group. With regard to body fat distribution, no statistically significant difference between cases and controls was found. Among the control women leptin levels were positively correlated with body fat distribution parameters (P<0.001).

【 授权许可】

Unknown   
© 2004 SAGE Publications