Clinical Evaluation of the Efficacy of a Barrier Cream Containing Polyvinylpyrrolidone in Chronic Hand Eczema

European Journal of Inflammation

Original Article

G.A. Vena¹  C. Malvindi²  M. Vestita²  D. Fai²  N. Carrino²  M.D. di Giuseppe²  P. Ligori²  G. Alessandrini²  R. Stasi²  P. Torsello²  A. Mancino²  N. Cassano²  M. Gabellone²  C. Calvi²  S. Pellè² 

[1] Prof. Gino A. Vena, M.D., MIDIM Department, Unit of Dermatology, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy, Tel./Fax: ++39 080 5478920, e-mail: ;Sezione Ionico-Salentina Associazione Dermatologi Magna Grecia, Italy;

关键词: hand dermatitis;    chronic eczema;    topical treatment;    barrier cream;    corticosteroids;   

DOI  :  10.1177/1721727X0800600305

 received in 2008-07-17, accepted in 2008-11-05,  发布年份 2008

来源: Sage Journals

【 摘 要 】

The management of chronic hand eczema is usually difficult. The aim of this open-label study is to assess the effectiveness and ‘steroid-sparing’ activity of a barrier cream containing polyvinylpyrrolidone in patients with chronic hand eczema. Rescue treatment with topical corticosteroids (TCs) was permitted in the event of eczema worsening, whereas preventive measures were maintained unchanged with respect to those adopted by patients in the past. Among the 207 participants, the main diagnosis was irritant contact dermatitis, followed by allergic contact dermatitis and atopic dermatitis. Nearly half of the patients (49%) applied the barrier cream once or twice a day, while the remaining patients used it three or more times per day. Regardless of rescue therapy with TCs, regular use of the barrier cream caused a progressive significant improvement of eczema severity, as indicated by dermatologists' and patients' assessments. A significant reduction in the amount of the TC applied in the last 3 months and in the number of TC treatment days during the previous 4 weeks was found at the end of 12-week treatment with the barrier cream as compared with baseline. The product was also well-tolerated and accepted by the majority of patients. The results of this study suggest that a barrier cream containing polyvinylpyrrolidone can represent a useful tool in the management of chronic hand eczema and may show steroid-sparing effects.

【 授权许可】

Unknown   
© 2008 SAGE Publications