Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy

Cell Transplantation

Review

Woei-Cherng Shyu¹  Shinn-Zong Lin²  Dah-Ching Ding³  Yu-Hsun Chang⁴ 

[1] Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan; Graduate Institute of Immunology, China Medical University, Taichung, Taiwan;Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan; Graduate Institute of Immunology, China Medical University, Taichung, Taiwan; China Medical University Beigang Hospital, Yunlin, Taiwan;Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan; Graduate Institute of Medical Science, Tzu Chi University, Hualien, Taiwan;Graduate Institute of Medical Science, Tzu Chi University, Hualien, Taiwan; Department of Pediatrics, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan;

关键词: Umbilical cord;    Wharton's jelly;    Clinical application;    Stem cells;   

DOI  :  10.3727/096368915X686841

 received in 2014-12-09, accepted in 2015-01-21,  发布年份 2015

来源: Sage Journals

【 摘 要 】

The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs). Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster self-renewal properties. Different derivation protocols may provide different amounts and populations of stem cells. Stem cell populations have also been reported in other compartments of the umbilical cord, such as the cord lining, perivascular tissue, and Wharton's jelly. HUCMSCs are noncontroversial sources compared to embryonic stem cells. They can differentiate into the three germ layers that promote tissue repair and modulate immune responses and anticancer properties. Thus, they are attractive autologous or allogenic agents for the treatment of malignant and nonmalignant solid and soft cancers. HUCMCs also can be the feeder layer for embryonic stem cells or other pluripotent stem cells. Regarding their therapeutic value, storage banking system and protocols should be established immediately. This review critically evaluates their therapeutic value, challenges, and future directions for their clinical applications.

【 授权许可】

Unknown   
© 2015 Cognizant Comm. Corp.