Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety

Breast Cancer: Basic and Clinical Research

Review

Michael J Kerin¹  Donald Courtney¹  Niamh O’Halloran¹  Aoife J Lowery² 

[1] Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland, Galway, Galway, Ireland;Graduate Entry Medical School, University of Limerick, Limerick, Ireland;

关键词: Breast reconstruction;    mastectomy;    adipose-derived stem cells;    tissue engineering;    adipose tissue engineering;    breast cancer;   

DOI  :  10.1177/1178223417726777

 received in 2017-04-27, accepted in 2017-07-13,  发布年份 2017

来源: Sage Journals

【 摘 要 】

Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.

【 授权许可】

CC BY   
© The Author(s) 2017

【 图 表 】

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