Polymer-Based Restoration of Left Ventricular Mechanics

Cell Transplantation

Article

Randall J. Lee¹  Hani N. Sabbah²  Robert Bauernschmitt³  Andy Hinson⁴  Sam Helgerson⁴ 

[1] Cardiovascular Research Institute, University of California-San Francisco, San Francisco, CA, USA;Department of Medicine, University of California-San Francisco, San Francisco, CA, USA;Institute for Regeneration Medicine, University of California-San Francisco, San Francisco, CA, USA;Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA;Isar Heart Center, IsarKliniken, Munich, Germany;LoneStar Heart, Inc., Laguna Hills, CA, USA;

关键词: Congestive heart failure (HF);    Left ventricular (LV) mechanics;    Tissue engineering;    Alginate hydrogel;   

DOI  :  10.3727/096368911X637461

 received in 2011-03-29, accepted in 2011-10-02,  发布年份 2013

来源: Sage Journals

【 摘 要 】

Heart failure continues to be a major health care concern with relatively few options for severely advanced heart failure patients. The hallmark of heart failure is the progressive dilatation of the left ventricle, thinning of the left ventricular wall leading to increased wall stress and increased myocardial oxygen consumption. Applying Laplace's law to the failing dilated ventricle, left ventricular augmentation utilizes a tissue engineering strategy to increase wall thickness and reduce chamber diameter, resulting in a decrease in wall stress and improved left ventricular function. A review of the rationale for an in situ tissue engineering approach for this treatment of heart failure and early clinical results of the Algisyl-LVR™ program are presented.

【 授权许可】

Unknown   
© 2013 Cognizant Comm. Corp.

【 图 表 】

Figure 13.

Figure 2.

Figure 12.