Enhanced Anti-Inflammatory Effects of Nanoencapsulated Diclofenac

European Journal of Inflammation

Letter to the Editor

H.S. Chiong¹  A. Zuraini¹  S.N. Tang¹  Z.A. Zakaria¹  J.Z. Goh¹  M.N. Hakim²  A.A. Kadir³  M.S.O. Fauzee⁴ 

[1] Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia;Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia; Sports Academy and Institute of Halal Product Research, University Putra Malaysia, Selangor, Malaysia;Faculty of Veterinary Medicine, University Putra Malaysia, Selangor, Malaysia;Northern University of Malaysia, Sintok, Kedah, Malaysia;

关键词: diclofenac;    liposome;    nanoencapsulation;    efficacy and anti-inflammation;   

DOI  :  10.1177/1721727X1301100328

 received in 2013-03-13, accepted in 2013-08-29,  发布年份 2013

来源: Sage Journals

【 摘 要 】

This study was conducted to compare the anti-inflammatory efficacy of nanoencapsulated and free-form diclofenac in rat. Diclofenac-loaded liposomes were prepared using the proliposome method. The anti-inflammatory effects of nanoencapsulated and free diclofenac were evaluated using the carrageenan-induced paw edema, formalin-induced paw licking and cotton-pellet-induced granuloma tests in vivo. For carrageenan-induced paw edema, 2 and 20 mg/kg liposome-encapsulated diclofenac showed significant paw volume reduction compared to free form diclofenac of equivalent dosage groups. In the formalin test, significant reduction in paw-licking time was observed in late phase for both liposome-encapsulated and free-form diclofenac (2 and 20 mg/kg) with the percentage of inhibition of 28.62, 60.17% for free-form diclofenac and 31.45, 78.84% for liposome-encapsulated diclofenac, respectively. In cotton-pellet-induced granuloma test 20 mg/kg free-form diclofenac showed significant reduction in the size of granuloma in both transudative and granuloma weight with percentage of inhibition of 42.93 and 49.26%, respectively, when compared to controls. Interestingly, 20 mg/kg nanoencapsulated diclofenac showed a larger reduction of the parameter with percentage of inhibition of 48.43 and 63.55%, respectively. Collectively, these results indicated that nanoencapsulated diclofenac exhibited statistically higher efficacy than free-form diclofenac when orally administered. Hence, clinical dosage may be reduced thereby reducing the drug's adverse effects.

【 授权许可】

Unknown   
© 2013 SAGE Publications