Single-Blind Evaluation of Post-Tonsillectomy Pain Treatment with an Eutectic Mixture of Local Anesthetics

European Journal of Inflammation

Diseases and Inflammation

G. Neri¹  C. Baffa²  E. Ballone²  F. Vitullo²  R. Di Mascio² 

[1] Giampiero Neri, c/o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy, Tel/Fax:[phone], e-mail: ;Medicine and Ageing Science Department, Laboratory of Biostatistics, University of Chieti, Chieti, Italy;

关键词: tonsillectomy;    pain;    lidocaine;    prilocaine;   

DOI  :  10.1177/1721727X0600400307

 received in 2006-03-17, accepted in 2006-10-05,  发布年份 2006

来源: Sage Journals

【 摘 要 】

The efficacy of an eutectic mixture of local anesthetics (lidocaine and prilocaine) in ointment for topical use (EMLA) in the treatment of post-tonsillectomy pain in both pediatric and adult patients was evaluated. Ninety patients affected by recurring tonsillitis and refractory to antibiotic therapy were submitted to tonsillectomy by dissection. Of the ninety patients 45 random subjects received topical treatment and the remaining 45 did not receive any treatment in the emptied tonsillar compartment. Pain intensity was evaluated at 3, 6 and 9 hours after surgical treatment using a visual subjective evaluation scale (VAS for adults and FES for children). The percentage of adults who referred pain of minor intensity was greater in the treated patients than in the controls: 51.4% vs 14.3% (p<0.001) at the third hour, 71.4% vs 2.9% (p<0.001) at the sixth hour and 88.6% vs 14.3% (p<0.001) at the ninth hour. In the pediatric groups, 80.0% of the treated subjects referred moderate pain at the third hour, compared to 40% of the control group. At the ninth hour all children (100%) referred moderate pain compared to 20% of the control group. No treated patient required analgesic therapy during the post-operative observation period. The application of EMLA in the compartment after tonsillectomy determined an extremely significant reduction of postoperative pain in terms of intensity and duration.

【 授权许可】

Unknown   
© 2006 SAGE Publications