Impact of Immunity in Autism Spectrum Disorders

European Journal of Inflammation

Editorial

S. Tetè¹  G. Varvara¹  D. Tripodi¹  G. Murmura¹  F. Pandolfi²  E. Cianchetti³  A. Saggini⁴  M. Rosati⁵  P. Conti⁶  E. Toniato⁶  T.C. Theoharides⁷  A. Caraffa⁸  P. Antinolfi⁸  G. Potalivo⁸  G. Maccauro⁹  M. Fulcheri^1,10 

[1] Dental School, University of Chiet-Pescarai, Chieti, Italy;Department of Medicine, Catholic University of Rome, Rome, Italy;Department of Surgery, Ortona ASL Hospital, Ortona, Italy;Dermatology Department, University Tor Vergata, Rome, Italy;Gynecology Division, Pescara Hospital, Italy;Immunology Division, Medical School, University of Chieti-Pescara, Italy;Internal Medicine and Biochemistry, Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Drug Discovery Laboratory, Tufts-New England Medical Center, Boston, MA, USA;Orthopeadics Division, University of Perugia, Italy;Orthopedics Division, Università Cattolica, Rome, Italy;Psychology School, University of Chieti-Pescara, Italy;

关键词: autism spectrum disorders;    cytokines;    inflammation;    immunity;   

DOI  :  10.1177/1721727X1301100103

 received in 2012-11-30, accepted in 2013-02-18,  发布年份 2013

来源: Sage Journals

【 摘 要 】

Autism spectrum disorders (ASDs) are childhood psychopathologies characterized by having difficulties in social interaction, verbal and non-verbal communication as well as sensor motor movements. Evidence suggests that in ASDs environmental toxicant exposure, genetic and mitochondrial dysfunction are involved associated with abnormal immune response with allergic problems and elevated serum IgE. ASDs present the major cytokine and chemokine dysfunction in CNS and is mediated by an increase of pro-inflammatory cytokine levels in the brain, such as TNF, IL-1, IFN-γ, IL-6, IL-8 and others. Mast cells, which are also implicated in ASDs, are worsened by stress and produce proinflammatory cytokines and can be stimulated by neurotensin in the brain and gut, contributing also to the inflammatory response. However, the exact etiology of ASDs remains largely unknown.

【 授权许可】

Unknown   
© 2013 SAGE Publications