Activation of the Bradykinin System by Angiotensin-Converting Enzyme Inhibitors

European Journal of Inflammation

Editorial

J.N. Sharma¹ 

[1] Prof. Dr. Jagdish N. Sharma, Department of Applied Therapeutics, Faculty of Pharmacy, Health Sciences Centre, Kuwait University, PO Box 24923, Safat 13110, Kuwait, Tel: ++965 2498 6530 (Office) Fax: ++965 2534 2807, e-mail: ;

关键词: angiotensin-converting enzyme inhibitors;    mechanism of action;    bradykinin system;    hypertension;   

DOI  :  10.1177/1721727X1000800201

 received in 2010-04-16, accepted in 2010-06-18,  发布年份 2010

来源: Sage Journals

【 摘 要 】

The Bradykinin (BK) system has a very significant role in the regulation of blood pressure (BP). Hence, reduced activity of BK receptors mediated via decreased circulating endogenous kinin might explain the cause of high BP. This system also governs the activation of the angiotensin system at various axes in control of the physiological BP. The BK receptor antagonists can block the hypotensive action of angiotensin-converting enzyme inhibitors (ACEIs) in hypertensive and normotensive animals. The hypotensive action of BK is highly increased with ACEIs or kininase II inhibitor treatment. The development of specific BK agonists may provide a new direction to explore the experimental approach for examining the role of BK in hypertension.

【 授权许可】

Unknown   
© 2010 SAGE Publications