Pharmacotherapy of Essential Tremor

Journal of Central Nervous System Disease

Article

FrantišEk Cibulčík¹  Peter Hedera²  Thomas L. Davis² 

[1] Department of Neurology, Slovak Medical University and University Hospital Bratislava, Slovakia.;Department of Neurology, Vanderbilt University, Nashville, TN.;

关键词: essential tremor;    pathogenesis;    propranolol;    primidone;    topiramate;    gabapentin;    pregabalin;   

DOI  :  10.4137/JCNSD.S6561

 received in 2013-10-01, accepted in 2013-11-01,  发布年份 2013

来源: Sage Journals

【 摘 要 】

Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients.

【 授权许可】

CC BY-NC   
© 2013 SAGE Publications.

【 图 表 】

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