Understanding Celiac Disease From Genetics to the Future Diagnostic Strategies

Clinical Medicine Insights: Gastroenterology

Review

Carolina Salazar¹  Jennyfer M García-Cárdenas¹  César Paz-y-Miño² 

[1] Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Quito, Ecuador;César Paz-y-Miño, Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial. Mariscal Sucre Ave. and Mariana de Jesús, Block I, 3rd floor, 170527, Ecuador. Email: ;

关键词: Celiac disease;    HLA;    gluten;    polymorphisms;   

DOI  :  10.1177/1179552217712249

 received in 2017-02-03, accepted in 2017-05-04,  发布年份 2017

来源: Sage Journals

【 摘 要 】

Celiac disease (CD) is an autoimmune disorder characterized by the permanent inflammation of the small bowel, triggered by the ingestion of gluten. It is associated with a number of symptoms, the most common being gastrointestinal. The prevalence of this illness worldwide is 1%. One of the main problems of CD is its difficulty to be diagnosed due to the various presentations of the disease. Besides, in many cases, CD is asymptomatic. Celiac disease is a multifactorial disease, HLA-DQ2 and HLA-DQ8 haplotypes are predisposition factors. Nowadays, molecular markers are being studied as diagnostic tools. In this review, we explore CD from its basic concept, manifestations, types, current and future methods of diagnosis, and associated disorders. Before addressing the therapeutic approaches, we also provide a brief overview of CD genetics and treatment.

【 授权许可】

CC BY-NC   
© The Author(s) 2017

【 图 表 】

Figure 6.

Figure 11.

Figure 8.

Figure 4.

Figure 3.

Figure 6.

Fig. 2

Figure 2.