Mechanical Intervention for Maintenance of Cartilage and Bone

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

Review

Luis Cardoso¹  Hiroki Yokota²  Hui B. Sun³ 

[1] Department of Biomedical Engineering, City College of New York, New York, NY 10031, USA.;Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.;Leni and Peter W. May Department of Orthopedic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA.;

关键词: joint motion;    knee loading;    arthritis;    tissue degradation;    bone formation;   

DOI  :  10.4137/CMAMD.S6982

来源: Sage Journals

【 摘 要 】

Mechanical loading provides indispensible stimuli for growth and development of the articular cartilage and bone. Interestingly, depending on loading conditions loads applied to the joint can be beneficial as well as harmful to skeletal maintenance and remodeling. Moderate loads to the synovial joint, for instance, suppress the expression levels of matrix metallproteinases (MMPs), while loads above a threshold tend to increase their destructive activities. This report focuses on two recently developed loading modalities from animal studies, joint motion and joint loading. Their unique characteristics and potential usages for maintenance of the articular cartilage and stimulation of bone remodeling are reviewed. Also described are biophysical and molecular mechanisms which likely are responsible for the load-driven maintenance of cartilage and bone, and a possibility of developing load-mediated treatments of osteoporosis and osteoarthritis.

【 授权许可】

CC BY-NC   
© 2011 SAGE Publications.

【 图 表 】

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Figure 2.

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