European Journal of Inflammation | |
The Safety of Immunotherapy in Patients with Allergic Asthma and Allergic Rhinitis | |
Allergy and Inflammation | |
M. Trakatelli1  G. Anogianakis2  A. Anogeianaki2  E. K. Theofilogiannakos2  D. Economidis3  G. Ilonidis4  C. Giannakoylas4  | |
[1] Department of Biochemistry, Aristotle University of Thessaloniki;Laboratory of Experimental Physiology of Aristotle University of Thessaloniki;Second Internal Medicine Clinic of Aristotle University of Thessaloniki, Greece;Fourth Internal Medicine Clinic of Aristotle University of Thessaloniki, Pneumology and Allergy Laboratory, Hippokration Hospital of Thessaloniki; | |
关键词: immunotherapy; systemic reactions; allergens; allergic rhinitis; allergic asthma; | |
DOI : 10.1177/1721727X0500300106 | |
received in 2004-09-04, accepted in 2004-12-05, 发布年份 2005 | |
来源: Sage Journals | |
【 摘 要 】
We studied systemic reactions associated with immunotherapy in a group of 50 patients with mean age 31.4 years. The group consisted of 36 women and 14 men who followed a three-year immunotherapy treatment with pollen and mite allergen extracts (HAL-Holland Corporation). A total number of 2550 injections were administered. Eight patients developed systemic reactions; 6 had allergic rhinitis and 2 allergic asthma. None developed severe anaphylaxis. Seven of the systemic reactions occurred immediately after injection while one was a late reaction manifested as generalized urticaria, local edema and rubor at the site of the injection. From the 7 patients who showed an immediate reaction, 5 developed generalized urticaria with local edema and rubor at the site of the injection, while 2 presented with bronchial spasm. We did not observe any reaction when the quantity of the extract injection was reduced by 50%. Our study points out that, in the vast majority of cases, immunotherapy is free of severe systemic reactions. Those that occur are associated with the injection of high-density extracts and none of them is severe.
【 授权许可】
Unknown
© 2005 SAGE Publications
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202212204795683ZK.pdf | 557KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]