The Safety of Immunotherapy in Patients with Allergic Asthma and Allergic Rhinitis

European Journal of Inflammation

Allergy and Inflammation

M. Trakatelli¹  G. Anogianakis²  A. Anogeianaki²  E. K. Theofilogiannakos²  D. Economidis³  G. Ilonidis⁴  C. Giannakoylas⁴ 

[1] Department of Biochemistry, Aristotle University of Thessaloniki;Laboratory of Experimental Physiology of Aristotle University of Thessaloniki;Second Internal Medicine Clinic of Aristotle University of Thessaloniki, Greece;Fourth Internal Medicine Clinic of Aristotle University of Thessaloniki, Pneumology and Allergy Laboratory, Hippokration Hospital of Thessaloniki;

关键词: immunotherapy;    systemic reactions;    allergens;    allergic rhinitis;    allergic asthma;   

DOI  :  10.1177/1721727X0500300106

 received in 2004-09-04, accepted in 2004-12-05,  发布年份 2005

来源: Sage Journals

【 摘 要 】

We studied systemic reactions associated with immunotherapy in a group of 50 patients with mean age 31.4 years. The group consisted of 36 women and 14 men who followed a three-year immunotherapy treatment with pollen and mite allergen extracts (HAL-Holland Corporation). A total number of 2550 injections were administered. Eight patients developed systemic reactions; 6 had allergic rhinitis and 2 allergic asthma. None developed severe anaphylaxis. Seven of the systemic reactions occurred immediately after injection while one was a late reaction manifested as generalized urticaria, local edema and rubor at the site of the injection. From the 7 patients who showed an immediate reaction, 5 developed generalized urticaria with local edema and rubor at the site of the injection, while 2 presented with bronchial spasm. We did not observe any reaction when the quantity of the extract injection was reduced by 50%. Our study points out that, in the vast majority of cases, immunotherapy is free of severe systemic reactions. Those that occur are associated with the injection of high-density extracts and none of them is severe.

【 授权许可】

Unknown   
© 2005 SAGE Publications