An Unusual Case of Infectious Mononucleosis Presenting with Advanced Lymphadenopathy and Ascites

European Journal of Inflammation

Letter to the Editor

H.C. Chen¹  Y.Y. Lin¹  C.P. Shih¹  C.Y. Kuo¹  F.S. Chiu¹  C.H. Wang² 

[1] Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China;Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China; Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, ROC; Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, Taipei, Taiwan, ROC;

关键词: infectious mononucleosis;    Epstein-Barr virus;    lymphoma;    lymphadenopathy;    F-fluoro-2-deoxy-D-glucose;    positron emission tomography;    polymerase chain reaction;   

DOI  :  10.1177/1721727X1301100122

 received in 2012-02-28, accepted in 2013-01-10,  发布年份 2013

来源: Sage Journals

【 摘 要 】

We report a case of infectious mononucleosis initially presented with lymphoma-like features. Examinations revealed abdominal ascites, splenomegaly, elevated lactic dehydrogenase, extensive lymphadenopathy from neck to the mediastinum, and a high 18F-fluoro-2-deoxy-D-glucose uptake pattern on positron emission tomography scan. The impression of lymphoma could not be ruled out based on the clinical manifestations, most importantly the diffuse necrosis with focal monotonous pattern and a high Ki-67 proliferation index found on pathological examination. Our presentation emphasizes the potential challenge in misdiagnosis of advanced infectious mononucleosis. Knowledge of its unusual clinical features is therefore essential to avoid misdirected interventions when it mimics diseases like lymphoma.

【 授权许可】

Unknown   
© 2013 SAGE Publications