Mechanisms of Acantholysis in Pemphigus: Mechanical or Inflammatory?

European Journal of Inflammation

Review Article

C. Feliciani¹  P. Amerio²  G. Caldarola²  A. Zampetti² 

[1] Prof. Claudio Feliciani, Department of Dermatology, Catholic University, Largo Francesco Vito, 8, 00168 Rome, Italy, Tel: [phone] Fax: [phone], e-mail: ;Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy;

关键词: pemphigus;    citokyne;    acantholysis;    skin;    immune system;   

DOI  :  10.1177/1721727X0600400202

 received in 2005-11-21, accepted in 2006-06-06,  发布年份 2006

来源: Sage Journals

【 摘 要 】

Pemphigus is a rare autoimmune disease, involving the skin and mucous epithelia, characterized by flaccid blisters and erosions. Histologically, the basic abnormality in all forms of pemphigus is the separation of keratinocytes from one another, a process known as acantholysis. There is direct evidence that autoantibodies against desmoglein, a transmembrane desmosomal component, are critical in its pathogenesis, but the exact mechanism that induces acantholysis is yet unknown. Actually, different studies suggest three possible mechanisms: sterical impedance, intracellular signalling and apoptosis. Understanding these processes should show new therapeutic perspective.

【 授权许可】

Unknown   
© 2006 SAGE Publications