Diagnosis of a Nonpalpable Intraductal Papilloma without Radiological Abnormality by Nipple Discharge Smear Examination: A Case Report

Breast Cancer: Basic and Clinical Research

Case Report

Anshul Singh¹  Vatsala Misra¹  Pramela Antony Singh¹  Jitendra Singh Nigam² 

[1] Department of Pathology, MLN Medical College, Allahabad, India.;Department of Pathology, Saraswathi Institute of Medical Sciences, Anwarpur, Hapur, U.P., India.;

关键词: nipple discharge;    papillary neoplasms;    infarction;    HMWCK;    p63;   

DOI  :  10.4137/BCBCR.S14914

 received in 2014-02-16, accepted in 2014-03-14,  发布年份 2014

来源: Sage Journals

【 摘 要 】

Nipple discharge is the third most common breast complaint after breast pain and breast mass, most commonly associated with endocrine alterations and/or medications, pregnancy, lactation, post lactation, fibrocystic disease, intraductal papilloma, duct ectasia, nipple adenoma, infection, chronic mastitis, subareolar abscess, and least frequently, breast carcinoma. Cytological examination of nipple discharge (ND) is a noninvasive method of diagnosing the underlying breast pathology. We report a 46 year old female, who presented with pain and blood-mixed ND from the right breast with an impalpable mass. Cytological examination of the discharge was done and diagnosis of papillary neoplasm with degeneration, metaplasia, and atypia was given, which was further confirmed on histology and positive IHC for HMWCK and p63. Final diagnosis was intraductal papilloma of the lactiferous duct with squamous metaplasia and infarction. Differentiating benign papilloma from a carcinoma is challenging to the cytopathologist and requires clinicopathological correlation and a good knowledge of cytology.

【 授权许可】

CC BY-NC   
© 2014 SAGE Publications.

【 图 表 】

Figure 4.