Posttransplant Immune Activation

Cell Transplantation

Original Articles

Thomas Crepin¹  Didier Ducloux¹  Cecile Courivaud¹  Jamal Bamoulid¹  Jean-Michel Rebibou²  Philippe Saas³ 

[1] , UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France;Department of Nephrology, Dialysis, and Renal Transplantation, CHU Besançon, Besançon, France;, UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France;Department of Nephrology, Dialysis, and Renal Transplantation, CHU Dijon, Dijon, France;, UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France;EFS, UMR1098, Plateforme de BioMonitoring, Besançon, France;Université Bourgogne Franche-Comté (UBFC), UMR1098, Besançon, France;INSERM CIC-1431, Besançon, France;

关键词: CD8 T cells;    atherosclerosis;    cardiovascular diseases;    kidney transplantation;    immune senescence;    aging;   

DOI  :  10.1177/0963689717735404

 received in 2016-07-12, accepted in 2016-09-30,  发布年份 2017

来源: Sage Journals

【 摘 要 】

Cardiovascular disease is a major cause of morbidity, disability, and mortality in kidney transplant patients. Cumulative reports indicate that the excessive risk of cardiovascular events is not entirely explained by the increased prevalence of traditional cardiovascular risk factors. Atherosclerosis is a chronic inflammatory disease, and it has been postulated that posttransplant immune disturbances may explain the gap between the predicted and observed risks of cardiovascular events. Although concordant data suggest that innate immunity contributes to the posttransplant accelerated atherosclerosis, only few arguments plead for a role of adaptive immunity. We report and discuss here consistent data demonstrating that CD8+ T cell activation is a frequent posttransplant immune feature that may have pro-atherogenic effects. Expansion of exhausted/activated CD8+ T cells in kidney transplant recipients is stimulated by several factors including cytomegalovirus infections, lymphodepletive therapy (e.g., antithymocyte globulins), chronic allogeneic stimulation, and a past history of renal insufficiency. This is observed in the setting of decreased thymic activity, a process also found in elderly individuals and reflecting accelerated immune senescence.

【 授权许可】

CC BY-NC   
© The Author(s) 2017

【 图 表 】

Figure 12.