Hepatitis C is Associated with High Levels of Circulating N-Terminal Pro-Brain Natriuretic Peptide and Interleukin-6

European Journal of Inflammation

Letter to the Editor

M.R. Metelli¹  F. Bruschi²  C. Ferri³  S.M. Ferrari⁴  S. Marchi⁴  N. De Bortoli⁴  A. Di Domenicantonio⁴  C. Mancusi⁴  A. Antonelli⁴  P. Fallahi⁴ 

[1] Department of Clinical Biochemistry and Molecular Biology, University of Pisa, Pisa, Italy;Department of Experimental Pathology and B.M.I.E., University of Pisa School of Medicine, Pisa, Italy;Department of Internal Medicine, Rheumatology Unit, University of Modena & Reggio E. School of Medicine, Modena, Italy;Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy;

关键词: N-terminal pro-brain natriuretic peptide;    HCV chronic infection;    cytokines;    heart failure;    cardiac;    dysfunction;    IL-6;    Interferon-gamma;   

DOI  :  10.1177/1721727X1201000117

 received in 2011-02-14, accepted in 2011-12-18,  发布年份 2012

来源: Sage Journals

【 摘 要 】

To our knowledge, no study has evaluated N-terminal pro-brain natriuretic peptide (NTproBNP) together with interleukin-6 (IL-6) and interferon (IFN)-gamma serum levels in a large series of patients with hepatitis C virus (HCV) as possible markers of cardiac dysfunction. NTproBNP and IL-6 serum levels were valued in 55 HCV-patients, and in 55 sex- and age-matched controls. HCV-patients showed significantly higher mean NTproBNP and IL-6 levels than controls (P = 0.001); no significant difference was observed for IFN-gamma. By defining high NTproBNP level as a value higher than 300 pg/mL (that is used to rule out heart failure in patients under 75 years of age), 12% (6/49) of HCV-patients and 0 of controls had NTproBNP (χ2; P = 0.012). In conclusion, this study demonstrates high levels of circulating NTproBNP and IL-6 in HCV-patients. The increase of NTproBNP may indicate the presence of a subclinical cardiac dysfunction. Further prospective studies quantifying symptoms and correlating these with echocardiography parameters are needed to confirm this association.

【 授权许可】

Unknown   
© 2012 SAGE Publications