Hepatocyte Transplantation: Clinical Experience and Potential for Future Use

Cell Transplantation

Article

Toshio Miki¹  Keitaro Mitamura¹  Ewa Ellis¹  Hongbo Cai¹  Thomas Lehmann¹  Stephen C. Strom²  Paolo Bruzzone³ 

[1] Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA;Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA;McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA;Department of Surgery and Transplantation “Paride Stefanini”, University of Rome “La Sapienza”, Rome, Italy;

关键词: Hepatocyte transplantation;    Clinical experience;    Future use;   

DOI  :  10.3727/000000006783982395

来源: Sage Journals

【 摘 要 】

Hepatocyte transplantation has been proposed as a method to support patients with liver insufficiency. There are three main areas where the transplantation of isolated hepatocytes has been proposed and used for clinical therapy. Cell transplantation has been used: 1) for temporary metabolic support of patients in end-stage liver failure awaiting whole organ transplantation, 2) as a method to support liver function and facilitate regeneration of the native liver in cases of fulminant hepatic failure, and 3) in a manner similar to gene therapy, as a “cellular therapy” for patients with genetic defects in vital liver functions. We will briefly review the basic research that leads to clinical hepatocyte transplantation, the published clinical experience with this experimental technique, and some possible future uses of hepatocyte transplantation.

【 授权许可】

Unknown   
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