Substance Use Disorder, Intravenous Injection, and HIV Infection: A Review

Cell Transplantation

Reviews

Shao-Cheng Wang¹  Brion Maher² 

[1] Jianan Psychiatric Center Ministry of Health and Welfare, Tainan, Taiwan;Mental Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;Mental Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;

关键词: substance use disorder;    HIV risk behavior;    intravenous drug injection;   

DOI  :  10.1177/0963689719878380

 received in 2019-03-27, accepted in 2019-09-04,  发布年份 2019

来源: Sage Journals

【 摘 要 】

DSM-V-defined substance use disorder comprises four groups of symptoms: impaired control, social impairment, risky use, and pharmacological reactions. Behavioral patterns of impaired control, including impulsivity and risk taking, are associated with HIV risk behaviors. Substance users with stronger craving symptoms are more likely to use drugs via intravenous injection than other routes because of the faster drug effect and the higher bioavailability; thus, they are at high risk of HIV infection. HIV risk behaviors such as unprotected sex and intravenous injection facilitate HIV disease spread. Public health policies such as Needle and Syringe Exchange Programs and medication-assisted treatment are proven to reduce HIV risk behaviors such as the frequency of intravenous injection and even the incidence of HIV infection, but both of them have limitations. While intravenous injection is a frequently discussed issue in public policies and the HIV-related literature, it is a much less frequent topic in the addiction literature. We believed that understanding the mental substrate behind impulsivity/risk taking and the possible biological mechanism of intravenous injection may help in creating more effective strategies to slow down HIV infection.

【 授权许可】

CC BY-NC   
© The Author(s) 2019