Immunological Changes in Mesothelioma Patients and Their Experimental Detection

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine

Review

Yasumitsu Nishimura¹  Megumi Maeda¹  Naoko Kumagai¹  Naomi Miyahara¹  Tamayo Hatayama¹  Shuko Murakami¹  Minako Katoh¹  Yoshie Miura¹  Hiroaki Hayashi¹  Shoko Yamamoto¹  Takemi Otsuki¹  Takashi Nakano²  Kazuya Fukuoka²  Takumi Kishimoto³ 

[1] Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 7010192, Japan.;Department of Respiratory Medicine, Hyogo Medical College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 6638131, Japan.;Okayama Rosai Hospital, 1-10-25 Chikkou-midori-machi, Okayama 7028055, Japan.;

关键词: asbestos;    immunology;    mesothelioma;    chrysotile;   

DOI  :  10.4137/CCRPM.S577

来源: Sage Journals

【 摘 要 】

It is common knowledge that asbestos exposure causes asbestos-related diseases such as asbestosis, lung cancer and malignant mesothelioma (MM) not only in people who have handled asbestos in the work environment, but also in residents living near factories that handle asbestos. These facts have been an enormous medical and social problem in Japan since the summer of 2005. We focused on the immunological effects of asbestos and silica on the human immune system. In this brief review, we present immunological changes in patients with MM and outline their experimental detection. For example, there is over-expression of bcl-2 in CD4+ peripheral T-cells, high plasma concentrations of interleukin (IL)-10 and transforming growth factor (TGF)-β, and multiple over-representation of T cell receptor (TcR)-VB in peripheral CD3+ T-cells found in MM patients. We also detail an experimental long-term exposure T-cell model. Analysis of the immunological effects of asbestos may help our understanding of the biological effects of asbestos.

【 授权许可】

CC BY   
© 2008 SAGE Publications.

【 图 表 】

Figure 4.