Stem Cell-Based Therapy for Spinal Cord Injury

Cell Transplantation

Review

Shom Shanker Bhattacharya¹  Slaven Erceg²  Vladislav Volarevic³  Petra Stojkovic⁴  Miodrag Stojkovic⁴  Philip Horner⁵ 

[1] CABIMER, Seville, Spain;CABIMER, Seville, Spain; Medical Genome Project, Seville, Spain;Center for Molecular Medicine and Stem Cell Research, Medical Faculty, University of Kragujevac, Serbia;Center for Molecular Medicine and Stem Cell Research, Medical Faculty, University of Kragujevac, Serbia; SPEBO MEDICAL, Leskovac, Serbia;Program in Neurobiology and Behavior, University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA;

关键词: Stem cells (SCs);    Spinal cord injury (SCI);    Differentiation;    Remyelination;    Inflammation;   

DOI  :  10.3727/096368912X657260

 received in 2012-01-05, accepted in 2012-05-23,  发布年份 2013

来源: Sage Journals

【 摘 要 】

Stem cells (SCs) represent a new therapeutic approach for spinal cord injury (SCI) by enabling improved sensory and motor functions in animal models. The main goal of SC-based therapy for SCI is the replacement of neurons and glial cells that undergo cell death soon after injury. Stem cells are able to promote remyelination via oligodendroglia cell replacement to produce trophic factors enhancing neurite outgrowth, axonal elongation, and fiber density and to activate resident or transplanted progenitor cells across the lesion cavity. While several SC transplantation strategies have shown promising yet partial efficacy, mechanistic proof is generally lacking and is arguably the largest impediment toward faster progress and clinical application. The main challenge ahead is to spur on cooperation between clinicians, researchers, and patients in order to define and optimize the mechanisms of SC function and to establish the ideal source/s of SCs that produce efficient and also safe therapeutic approaches.

【 授权许可】

Unknown   
© 2013 Cognizant Comm. Corp.

【 图 表 】

Figure 2