C-Reactive Protein Level and its Relationship with Suicide Risk and Alexithymia among Newly Diagnosed, Drug-Naïve Patients with Non-Affective Psychosis

European Journal of Inflammation

Original Article

G. Di Iorio¹  G. Martinotti¹  M. Di Giannantonio¹  A. Carano²  M. Fornaro³  G. Perna⁴  A. Valchera⁵  F. Iasevoli⁶  R.S. Moschetta⁷  N. Serroni⁷  C.M. Conti⁸  D. De Berardis⁹  S. Marini⁹  A. Siracusano^1,10  C. Niolu^1,10 

[1]Department of Neuroscience and Imaging, Chair of Psychiatry, University “G D'Annunzio”, Chieti, Italy

[2]Department of Neuroscience and Imaging, Chair of Psychiatry, University “G D'Annunzio”, Chieti, Italy

[3] National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, “C. G. Mazzoni” Hospital, Ascoli Piceno, Italy

[4]Department of “Scienze della Formazione”, University of Catania, Italy

[5]Hermanas Hospitalarias, FoRiPsi, Department of Clinical Neurosciences, Villa San Benedetto Menni, Albese con Cassano, Como, Italy

[6] Department of Psychiatry and Behavioral Sciences, Leonard Miller School of Medicine, University of Miami, USA

[7] Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands

[8]Hermanas Hospitalarias, FoRiPsi, Villa S. Giuseppe Hospital, Ascoli Piceno, Italy

[9]Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, University School of Medicine “Federico II”, Naples, Italy

[10]National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, “G. Mazzini” Hospital, Teramo, Italy

[11]National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, “G. Mazzini” Hospital, Teramo, Italy

[12] Department of Clinical Psychology, University “G. D'Annunzio”, Chieti, Italy

[13]National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, “G. Mazzini” Hospital, Teramo, Italy

[14] Department of Neuroscience and Imaging, Chair of Psychiatry, University “G D'Annunzio”, Chieti, Italy

[15]Psychiatric Unit, Tor Vergata University, Rome, Italy

关键词: C-reactive protein;    suicide risk;    alexithymia;    depression;    psychosis;    drug-naive;   

DOI  :  10.1177/1721727X1301100120

 received in 2012-02-29, accepted in 2013-01-08,  发布年份 2013

来源: Sage Journals

【 摘 要 】

The aim of the present study was to evaluate C-Reactive Protein (CRP) levels in newly diagnosed drug-naïve patients with non-affective psychosis, testing the hypotheses that in such patients serum CRP levels would be higher than in healthy controls and related to more severe psychopathology, suicide risk and alexithymia. CRP levels of 30 adult patients and 30 sex- and age-matched healthy controls were evaluated. Patients were tested with the Scale of Suicide Ideation (SSI), the Toronto Alexithymia Scale (TAS-20), the Scale for the Assessment of Positive and Negative Symptoms (SAPS and SANS) and the Calgary Depression Scale for Schizophrenia (CDSS). Higher suicide risk patients showed higher CRP levels than lower suicide risk patients and healthy controls. Moreover, such patients showed higher SAPS, SANS and CDSS scores than lower suicide risk patients. In linear regression model, CRP was significantly associated with higher SSI and TAS-20 scores. The results of the present study support the notion that CRP, suicide risk and alexithymia are strictly linked in newly diagnosed, drug-naïve patients with non-affective psychosis, independently of depressive symptoms or general psychopathology. Limitations are discussed.

【 授权许可】

Unknown   
© 2013 SAGE Publications