Towards a Protocol for the Preparation and Delivery of Striatal Tissue for Clinical Trials of Transplantation in Huntington's Disease

Cell Transplantation

Article

Stephen B. Dunnett¹  Colin Watts² 

[1] MRC Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK;Departments of Experimental Psychology, University of Cambridge, Cambridge, UK;MRC Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK;Departments of Neurosurgery University of Cambridge, Cambridge, UK;

关键词: Huntington's disease;    Donor tissue preparation;    Clinical trial protocol;   

DOI  :  10.1177/096368970000900208

来源: Sage Journals

【 摘 要 】

There is a growing body of scientific evidence contributing to the development of clinical transplantation programs in patients with Huntington's disease. Phase I clinical trials have already commenced in France and North America and are starting in the near future in Sweden and the UK. Protocols for patient selection, surgical implantation, and pre- and postoperative follow-up are well defined. However, considerable variability exists with respect to the harvesting, preparation, and timing of implantation of the donor material. In this article we review the scientific evidence on which a rational protocol for donor tissue preparation and delivery may be based. Strategies aimed at minimizing the variability of tissue preparation should reduce the variability of functional outcome of striatal transplantation observed in animal models of Huntington's disease.

【 授权许可】

Unknown   
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