Fusobacterium nucleatum exacerbates chronic obstructive pulmonary disease in elastase‐induced emphysematous mice

FEBS Open Bio

Kenichi Imai¹  Noriaki Kamio¹  Tadayoshi Kaneko²  Ryuta Suzuki²  Yoshiyuki Yonehara² 

[1] Department of Microbiology Nihon University School of Dentistry Tokyo Japan;Department of Oral and Maxillofacial Surgery II Nihon University School of Dentistry Tokyo Japan;

关键词: chronic obstructive pulmonary disease;    COPD exacerbations;    emphysema;    Fusobacterium nucleatum;    periodontal disease;   

DOI  :  10.1002/2211-5463.13369

来源: DOAJ

【 摘 要 】

Exacerbation of chronic obstructive pulmonary disease (COPD) is associated with disease progression and increased mortality. Periodontal disease is a risk factor for exacerbation of COPD, but little is known about the role of periodontopathic bacteria in this process. Here, we investigated the effects of intratracheal administration of Fusobacterium nucleatum, a periodontopathic bacteria species, on COPD exacerbation in elastase‐induced emphysematous mice. The administration of F. nucleatum to elastase‐treated mice enhanced inflammatory responses, production of alveolar wall destruction factors, progression of emphysema, and recruitment of mucin, all of which are symptoms observed in patients with COPD exacerbation. Hence, we propose that F. nucleatum may play a role in exacerbation of COPD.

【 授权许可】

Unknown