Fabrication and In Vitro Evaluation of pH-Sensitive Polymeric Hydrogels as Controlled Release Carriers

Gels

Muhammad Usman Minhas¹  Arshad Khan²  Chih-Wun Fang³  Muhammad Suhail⁴  Pao-Chu Wu⁴ 

[1] College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan;Department of Pharmaceutics, Faculty of Pharmacy, Khawaja Fareed Campus (Railway Road), The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan;Divison of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung City 81342, Taiwan;School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung City 80708, Taiwan;

关键词: hydrogels;    swelling test;    drug release;   

DOI  :  10.3390/gels7030110

来源: DOAJ

【 摘 要 】

The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.

【 授权许可】

Unknown