Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users

Nutrients

Jose Lopez-Miranda¹  Javier A. Menendez²  Anna Hernández-Aguilera³  Jorge Joven³  Jordi Camps³  Noemi Cabre³  Salvador Fernández-Arroyo³  Fedra Luciano-Mateo³ 

[1] CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain;Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain;Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain;

关键词: diabetes mellitus;    energy intake;    epigenetics;    folic acid;    food-drug interactions;    food source;    obesity;    vitamins B;   

DOI  :  10.3390/nu9020121

来源: DOAJ

【 摘 要 】

Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.

【 授权许可】

Unknown