Diffuse primary cutaneous infection by Alternaria alternata in a liver transplant recipient with pulmonary nocardiosis: Importance of prompt identification for clinical resolution

Medical Mycology Case Reports

Simona Coladonato¹  Maddalena Giannella²  Nunzio Salfi³  Maria Cristina Morelli⁴  Caterina Campoli⁴  Monica Cricca⁴  Simone Ambretti⁴  Pier Luigi Viale⁵  Sara Ferraro⁵ 

[1] Pathology Unit, Giannina Gaslini Children's Research Hospital, Via Gerolamo Gaslini 5, 16147, Genova, Italy;Department for Care of Organ Failures and Transplants, Internal Medicine for the Treatment of Severe Organ Failures, Policlinico Sant'Orsola Malpighi, Via Massarenti 9, 40138, Bologna, Italy;Histopathology Unit, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy;Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna, Italy;Operative Unit of Clinical Microbiology, Policlinico Sant'Orsola Malpighi, Via Massarenti 9, 40138, Bologna, Italy;

关键词: Alternaria alternata;    Phaeohyphomycosis;    Nocardiosis;    Liver transplantation;    Immunocompromised host;   

DOI  :  

来源: DOAJ

【 摘 要 】

Fungal infections are rare in the general population but are an emerging cause of disease in immunosuppressed patients, especially solid organ transplant recipients. Here, we report the case of a female Caucasian liver transplant patient who developed pulmonary nocardiosis two months after an episode of liver rejection. At the time of lung nocardiosis, she was being treated with tacrolimus and corticosteroids and suffered from diffuse papular skin lesions. She was initially suspected of having a cutaneous nocardial infection but culture examination revealed the presence of a dematiaceous fungus; Alternaria alternata. The prompt identification of the fungus and administration of oral Voriconazole resolved the skin infection with complete remission.

【 授权许可】

Unknown