Firing up the cold tumors by targeting Vps34

OncoImmunology

Guy Berchem¹  Santiago Parpal²  Bassam Janji³  Muhammad Zaeem Noman³  Meriem Hasmim³ 

[1] Centre Hospitalier du Luxembourg;Sprint Bioscience;Tumor Immunotherapy and Microenvironment (TIME) Group;

关键词: autophagy;    vps34;    cold/hot tumors;    proinflammatory cytokines;    ccl5;    cxcl10;    immune landscape;    nk cells;    t cd8 lymphocytes;    cancer immunotherapy;    anti-pd-1/pd-l1;    melanoma;    colon cancer;   

DOI  :  10.1080/2162402X.2020.1809936

来源: DOAJ

【 摘 要 】

Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published in Science Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC.

【 授权许可】

Unknown