SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Italian Journal of Pediatrics

Davide Caimmi¹  Simona Barni²  Francesca Mori²  Giuseppe Crisafulli³  Carla Mastrorilli⁴  Carlo Caffarelli⁴  Dora Di Mauro⁴  Paolo Bottau⁵  Lucia Diaferio⁶  Fabio Cardinale⁷  Marzia Duse⁸  Stefania Arasi⁹  Pasquale Comberiati^1,10  Silvia Caimmi^1,11  Gianluigi Marseglia^1,12  Lucia Liotti^1,13  Francesco Paravati^1,14  Francesca Saretta^1,15  Umberto Pelosi^1,16  Fabrizio Franceschini^1,17 

[1] Allergy Unit, Departement de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve;Allergy Unit, Department of Pediatric, Anna Meyer Children’s University Hospital;Allergy Unit, Department of Pediatrics, University of Messina;Clinica Pediatrica, Department of Medicine and Surgery, University of Parma;Department of Paediatrics and Neonatology, Ospedale di Imola, Azienda USL;Department of Paediatrics, Aldo Moro University of Bari-Giovanni XXIII Hospital;Department of Pediatrics, Pediatric Hospital “Giovanni XXIII”, University of Bari;Department of Pediatrics, Policlinico Umberto I, Sapienza University of Rome;Pediatric Allergy Unit, Bambino Gesù Academic Hospital;Pediatric Clinic, Department of Life and Reproduction Sciences, University of Verona;Pediatric Clinic, Department of Pediatrics, University of Pavia;Pediatric Clinic, University of Pavia, IRCCS Policlinico “S. Matteo” Foundation;Pediatric Unit, Civic Hospital;Pediatric Unit, Infant Maternal Department, Azienda Sanitaria Provinciale Crotone;Pediatric Unit, Palmanova Hospital;Pediatric Unit, Santa Barbara Hospital;Pediatric Unit, “G. Salesi” Children Hospital;

关键词: Allergy;    Antibiotics;    Challenge;    Children;    Diagnosis;    Drug allergy;   

DOI  :  10.1186/s13052-018-0589-3

来源: DOAJ

【 摘 要 】

Abstract Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Different protocols through the administration of divided increasing doses have been postulated according to the type of drug and the onset of the reaction (immediate or non immediate reactions). DPT protocols differ in doses and time interval between doses. In this position paper, the Italian Pediatric Society for Allergy and Immunology provides a practical guide for provocation test to antibiotics and NSAIDs in children and adolescents.

【 授权许可】

Unknown