New Scabimycins A-C Isolated from Streptomyces acidiscabies (Lu19992)

Molecules

Josef Zapp¹  Constanze Paulus²  Andriy Luzhetskyy² 

[1] Department of Pharmaceutical Biology, Saarland University, 66123 Saarbrücken, Germany;Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbrücken, Germany;

关键词: Streptomyces;    peptide natural products;    α,β-dehydroamino acid;    advanced Marfey’s method;   

DOI  :  10.3390/molecules26195922

来源: DOAJ

【 摘 要 】

Peptide natural products displaying a wide range of biological activities have become important drug candidates over the years. Microorganisms have been a powerful source of such bioactive peptides, and Streptomyces have yielded many novel natural products thus far. In an effort to uncover such new, meaningful compounds, the metabolome of Streptomyces acidiscabies was analyzed thoroughly. Three new compounds, scabimycins A–C (1–3), were discovered, and their chemical structures were elucidated by NMR spectroscopy. The relative and absolute configurations were determined using ROESY NMR experiments and advanced Marfey’s method.

【 授权许可】

Unknown