Botulinum Neurotoxin for the Treatment of Neuropathic Pain

Frontiers in Neurology

Gabriella Egeo¹  Luisa Fofi¹  Piero Barbanti² 

[1] Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy;San Raffaele University, Rome, Italy;

关键词: botulinum toxin;    neuropathic pain;    pain treatments;    visual analog scale;    disability;   

DOI  :  10.3389/fneur.2020.00716

来源: DOAJ

【 摘 要 】

Botulinum neurotoxin is widely used for the treatment of central and peripherical neurological conditions. Initially used to treat strabismus, over the years its use has been expanded also to spasticity and other neurological disorders. This review summarizes the evidence from the published literature regarding its effect on neuropathic pain. Almost all investigations were performed using onabotulinum toxin type A (BoNT/A). Most studies provided positive results, even though toxin formulation, dose, dilution, injection techniques, and sites are heterogeneous across studies. Future larger, high-quality, specifically designed clinical trials are warranted to confirm botulinum neurotoxin efficacy in neuropathic pain.

【 授权许可】

Unknown