Immune Dysregulation and theIncreased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

Frontiers in Immunology

Ilario De Toma¹  Mara Dierssen¹  Jacqueline London²  William Mobley⁴  Andre Strydom⁷  Stylianos E. Antonarakis⁸  Eugene Yu^1,10  Yann Herault^1,11  Alexandra Botté^1,12  Marie-Claude Potier^1,12  Randall Roper^1,13  Benjamin Sredni^1,14  Eitan Okun^1,14  Maria Florencia Iulita^1,17  Lisi Flores-Aguilar^1,18  Arya Biragyn^1,19  Tomer Illouz^2,22 

[1] 0Biomedical Research Networking Center for Rare Diseases (CIBERER), Barcelona, Spain;0Université de Paris, BFA, UMR 8251, CNRS, Paris, France;1Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland;1Department of Neurosciences, University of California, San Diego, San Diego, CA, United States;2Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, United Kingdom;2Medigenome, Swiss Institute of Genomic Medicine, Geneva, Switzerland;3South London and Maudsley NHS Foundation Trust, London, United Kingdom;3iGE3 Institute of Genetics and Genomics of Geneva, Geneva, Switzerland;4The Children’s Guild Foundation Down Syndrome Research Program, Genetics and Genomics Program and Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States;5Genetics, Genomics and Bioinformatics Program, State University of New York at Buffalo, Buffalo, NY, United States;6Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire et Cellulaire, IGBMC - UMR 7104 - Inserm U1258, Illkirch, France;7Paris Brain Institute (ICM), CNRS UMR7225, INSERM U1127, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France;8Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, United States;9The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel;Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain;Center for Genomic Regulation, The Barcelona Institute for Science and Technology, Barcelona, Spain;Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain;Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada;Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health, Baltimore, MD, United States;Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel;The Paul Feder Laboratory on Alzheimer’s Disease Research, Bar-Ilan University, Ramat Gan, Israel;University Pompeu Fabra, Barcelona, Spain;

关键词: Down syndrome;    immune dysregulation;    hospitalization;    respiratory tract infections;    interferon;    COVID-19;   

DOI  :  10.3389/fimmu.2021.621440

来源: DOAJ

【 摘 要 】

The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.

【 授权许可】

Unknown