Phase II Study of Hypofractionated Proton Beam Therapy for Hepatocellular Carcinoma

Frontiers in Oncology

Young-Hwan Koh¹  Woo Jin Lee¹  Bo Hyun Kim¹  Sang Myung Woo¹  Joong-Won Park¹  Sang Soo Kim²  Tae Hyun Kim²  Eun Sang Oh²  Sang Hee Youn²  Sung Ho Moon²  Dae Yong Kim² 

[1] Center for Liver Cancer, Research Institute and Hospital, National Cancer Center, Goyang, South Korea;Center for Proton Therapy, Research Institute and Hospital, National Cancer Center, Goyang, South Korea;

关键词: hepatocellular carcinoma;    overall survival;    local progression-free survival;    proton beam therapy;    radiotherapy;   

DOI  :  10.3389/fonc.2020.00542

来源: DOAJ

【 摘 要 】

Background: Proton beam has an excellent depth dose distribution due to its unique physical properties, and thus proton beam therapy (PBT) has been tried and showed promising outcomes in hepatocellular carcinoma (HCC). The purpose of this phase II study is to evaluate the efficacy of hypofractionated PBT in HCC.Methods: The eligibility criteria for this study were as follows: patients with HCC lesion(s) who were failed after, were difficult to treat with, or refused to other local treatments; tumor size and number of ≤7 and ≤2 cm, respectively, and HCC lesion(s) of ≥2 cm from gastrointestinal organs; Child–Pugh score of ≤7; Eastern Cooperative Oncology Group performance status ≤1; and age ≥18 years. The prescribed dose of PBT was 70 Gy equivalent in 10 fractions. The primary endpoint was 3-year local progression-free survival (LPFS) rate.Results: Forty-five patients were prospectively enrolled, and there were 35 men and 10 women with a median age of 63 years (range, 46–78 years). Thirty-seven patients had recurrent and/or residual disease, and eight patients had treatment-naive disease. All patients received the planned treatments without treatment interruption, and grade ≥3 acute toxicity did not occur. The median follow-up duration was 35.1 months (range, 11.2–56.3 months) and local progression occurred in two patients (8.7%). The 3-year rates of LPFS and overall survival (OS) were 95.2% (95% confidence interval [CI], 89.1%−100%) and 86.4% (95% CI, 72.9–99.9%), respectively.Conclusion: Hypofractionated PBT showed promising LPFS and OS, and further studies are warranted to compare PBT with other local modalities.

【 授权许可】

Unknown