In-vitro antibacterial activity of the seed extract of three-member Artocarpus towards Methicillin-Resistant Staphylococcus aureus (MRSA)

Jurnal Teknologi Laboratorium

Aulia Bella Agmala¹  Muhammad Evy Prastiyanto¹  Zhafira Dias Radipasari¹  Bagus Dwi Yulianto¹  Nita Ayu Dwi Astuti¹  Inas Hasna Azizah¹  Hafizha Dara Haqi¹  Arifani Rahma Putri¹ 

[1] Department of Medical Laboratory Technology, Faculty of Nursing and Health Science, Universitas Muhammadiyah Semarang, Indonesia;

关键词: artocarpus;    antibacterial activity;    zones of inhibition;    methicillin resistant staphylococcus aureus;    minimum inhibitory concentration;    minimum bactericidal concentration;   

DOI  :  10.29238/teknolabjournal.v9i2.237

来源: DOAJ

【 摘 要 】

Methicillin-Resistant Staphylococcus aureus (MRSA) infections have created a critical need for the development of natural antibacterials from a biological source. This research aimed to investigate the antibacterial activity of the seed extract of three-member Artocarpus (Artocarpus heterophyllus, A. champeden, and A. camansi) against MRSA which are the most prevalent causes of infections in patients. Crude seed extracts of three-member Artocarpus were evaluated for their antibacterial activity against MRSA. The antibacterial activity against MRSA of the three extracts was assayed in vitro by the agar well diffusion assay and agar microdilution method and minimum bactericidal concentration. The antibacterial activity, calculated as a zone of inhibition and MIC, MBC values. The Crude seed extracts of three-member Artocarpus showed antibacterial activity against the MRSA in the agar well diffusion assay (1.5-9 mm inhibition diameter). The MIC value of extract showed at 15.62 mg/mL and the MBC value of seed extract of A. heterophyllus at 62.5 mg/mL, A. champeden at 31.25 mg/mL, A. camansi at 250 mg/mL. All seed extracts have the potential to be developed as antibacterial agents, particularly against MRSA strain. Studies on the antibacterial activity against MRSA can provide new information about the benefits seed of members of Artocarpus as a source of natural antibacterial.

【 授权许可】

Unknown