Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver

Molecules

Hui Yang¹  Qin Li¹  Zhongbin Cheng¹  Wan Liu¹  Shouye Han¹  Yu Liu¹  Fan Yang¹  Jia Zhang¹ 

[1] School of Pharmacy, Henan University, Kaifeng 475004, China;

关键词: Aspergillus flavipes DZ-3;    asperflaloids A and B;    structural identification;    bioactivity;   

DOI  :  10.3390/molecules26123514

来源: DOAJ

【 摘 要 】

The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Eucommia ulmoides Oliver and identified as Aspergillus flavipes. Two new alkaloids, named asperflaloids A and B (1 and 2), together with 10 known compounds (3–12) were obtained from the EtOAc extract of the strain. Interestingly, the alkaloids 1–4 with different frameworks are characterized by the presence of the same anthranilic acid residue. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of asperflaloids A and B was resolved by quantum chemistry calculation. All compounds were screened for their inhibitions against α-glucosidase and the antioxidant capacities. The results were that compound 3 had an IC₅₀ value of 750.8 μM toward α-glucosidase, and the phenol compounds 7 and 8 exhibited potent antioxidant capacities with IC₅₀ values 14.4 and 27.1 μM respectively.

【 授权许可】

Unknown