Moringa oleifera Lam.ameliorates the muscles function recovery following an induced insult to the Sciatic nerve in a mouse model

Food Science & Nutrition

Shoaib Ahmad Malik¹  Muhammad Qasim²  Azhar Rasul³  Muhammad Imran⁴  Farhan Saeed⁵  Ali Imran⁵  Javeria Maqbool⁶  Syed Kashif Shahid Kamran⁶  Ghulam Hussain⁶  Aroona Razzaq⁶  Shamaila Zafar⁶  Muzzamal Hussain⁷ 

[1] Department of Biochemistry Sargodha Medical College University of Sargodha Sargodha Pakistan;Department of Bioinformatics and Biotechnology Faculty of Life Sciences Government College University Faisalabad Pakistan;Department of Zoology Faculty of Life Sciences Government College University Faisalabad Pakistan;Faculty of Allied Health Sciences University Institute of Diet and Nutritional Sciences The University of Lahore Lahore Pakistan;Institute of Home and Food Sciences Faculty of Life Sciences Government College University Faisalabad Pakistan;Neurochemicalbiology and Genetics Laboratory (NGL) Department of Physiology Faculty of Life Sciences Government College University Faisalabad Pakistan;University of Gambia Serrekunda Gambia;

关键词: blood glucose;    Moringa oleifera;    motor and sensory functional recovery;    peripheral nerve injury;    phytochemicals;   

DOI  :  10.1002/fsn3.1620

来源: DOAJ

【 摘 要 】

Abstract Peripheral nerve injury (PNI) is an incapacitating situation and has no effective therapy until now. We examined the possible role of crude leaves of Moringa oleifera Lam. at 200 mg/kg body weight in accelerating the functional regain in the sciatic nerve lesion induced mouse model (Adult male albino mice (BALB/c). Motor functions were evaluated by using the sciatic functional index, muscle mass, and muscle grip strength measurement, whereas the sensory functions were evaluated by using the hot plate test. Blood glucose levels and blood cell composition were also analyzed. We found that the Moringa oleifera crude leaves endorse the sensory and motor functions reclamation following the PNI with a statistically significant difference (p < .05). It also revitalizes the gastrocnemius muscle by mass restoration with glycemic management perspective. Conclusively, the crude powder of Moringa oleifera leaves exhibited a function restoration boosting property and further detailed studies for its application as a therapeutic agent are strongly recommended.

【 授权许可】

Unknown