Insights into HP1a-Chromatin Interactions

Cells

Mario Zurita¹  Victor E. Nieto-Caballero¹  Silvia Meyer-Nava¹  Viviana Valadez-Graham¹ 

[1] Instituto de Biotecnología, Departamento de Genética del Desarrollo y Fisiología Molecular, Universidad Nacional Autónoma de México, Cuernavaca Morelos 62210, Mexico;

关键词: heterochromatin;    HP1a;    genome stability;   

DOI  :  10.3390/cells9081866

来源: DOAJ

【 摘 要 】

Understanding the packaging of DNA into chromatin has become a crucial aspect in the study of gene regulatory mechanisms. Heterochromatin establishment and maintenance dynamics have emerged as some of the main features involved in genome stability, cellular development, and diseases. The most extensively studied heterochromatin protein is HP1a. This protein has two main domains, namely the chromoshadow and the chromodomain, separated by a hinge region. Over the years, several works have taken on the task of identifying HP1a partners using different strategies. In this review, we focus on describing these interactions and the possible complexes and subcomplexes associated with this critical protein. Characterization of these complexes will help us to clearly understand the implications of the interactions of HP1a in heterochromatin maintenance, heterochromatin dynamics, and heterochromatin’s direct relationship to gene regulation and chromatin organization.

【 授权许可】

Unknown