Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases

Molecules

Mario de la Fuente Revenga¹  Olaia Martí-Marí²  Clara Herrera-Arozamena²  María Isabel Rodríguez-Franco²  Martín Estrada² 

[1] Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA;Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), C/Juan de la Cierva 3, Madrid 28006, Spain;

关键词: adult neurogenesis;    serotonin system;    melatonin receptors;    Wnt/β-catenin pathway;    sigma receptors;    nicotinamide phosphoribosyltransferase;    nuclear erythroid 2-related factor;   

DOI  :  10.3390/molecules21091165

来源: DOAJ

【 摘 要 】

The central nervous system of adult mammals has long been considered as a complex static structure unable to undergo any regenerative process to refurbish its dead nodes. This dogma was challenged by Altman in the 1960s and neuron self-renewal has been demonstrated ever since in many species, including humans. Aging, neurodegenerative, and some mental diseases are associated with an exponential decrease in brain neurogenesis. Therefore, the controlled pharmacological stimulation of the endogenous neural stem cells (NSCs) niches might counteract the neuronal loss in Alzheimer’s disease (AD) and other pathologies, opening an exciting new therapeutic avenue. In the last years, druggable molecular targets and signalling pathways involved in neurogenic processes have been identified, and as a consequence, different drug types have been developed and tested in neuronal plasticity. This review focuses on recent advances in neurogenic agents acting at serotonin and/or melatonin systems, Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase (NAMPT) and nuclear erythroid 2-related factor (Nrf2).

【 授权许可】

Unknown