Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers

Advanced Science

Frank Scholle¹  Steven D. Smith²  Richard J. Spontak³  Jiaqi Yan³  Bharadwaja S. T. Peddinti³  Reza A. Ghiladi⁴  Roger Tocchetto⁵  Vijay Mhetar⁵  Anthony Griffiths⁶  Sierra N. Downs⁶ 

[1] Center for Advanced Virus Experimentation North Carolina State University Raleigh NC 27695 USA;Corporate Research & Development The Procter & Gamble Company Cincinnati OH 45224 USA;Department of Chemical & Biomolecular Engineering North Carolina State University Raleigh NC 27695 USA;Department of Chemistry North Carolina State University Raleigh NC 27695 USA;Kraton Innovation Center Kraton Corporation Houston TX 77084 USA;National Emerging Infectious Diseases Laboratories Boston University School of Medicine Boston MA 02118 USA;

关键词: antiviral materials;    charged block polymers;    microphase‐ordered materials;    polyanions;    thermoplastic elastomers;   

DOI  :  10.1002/advs.202003503

来源: DOAJ

【 摘 要 】

Abstract While the ongoing COVID‐19 pandemic affirms an urgent global need for effective vaccines as second and third infection waves are spreading worldwide and generating new mutant virus strains, it has also revealed the importance of mitigating the transmission of SARS‐CoV‐2 through the introduction of restrictive social practices. Here, it is demonstrated that an architecturally‐ and chemically‐diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces. Operating on a dramatic pH‐drop mechanism along the polymer/pathogen interface, polymers of this archetype inactivate the SARS‐CoV‐2 virus, as well as a human coronavirus surrogate (HCoV‐229E), to the minimum detection limit within minutes. Application of these anionic polymers to frequently touched surfaces in medical, educational, and public‐transportation facilities, or personal protection equipment, can provide rapid and repetitive protection without detrimental health or environmental complications.

【 授权许可】

Unknown