Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine

International Journal of Hematology-Oncology and Stem Cell Research

Ali Asghar Moghaddam¹  Roghayeh Hosseinikia²  Mahboobe Hosseinikia²  Yahya Pasdar²  Mohammad Reza Nikbakht³  Mahin Nikougoftar Zarif⁴  Kamran Mansouri⁵  Ahmad Tajehmiri⁵  Farhad Oubari⁵ 

[1] College of Veterinary Medicine, Razi University, Kermanshah, Iran;Department of Health Education and Nutrition, Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran;Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran;Iranian Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran;Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;

关键词: MSCs;    Immunomodulation;    Cell therapy;    Regeneration medicine;    Soluble factors;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic.

【 授权许可】

Unknown