Evaluating the profound effect of gut microbiome on host appetite in pigs

BMC Microbiology

Ming Yang¹  Shaoming Fang²  Hui Yang²  Xiaochang Huang²  Congying Chen²  Jun Gao²  Yunyan Zhou²  Lusheng Huang²  Jinyuan Wu²  Shanlin Ke²  Hao Fu²  Maozhang He² 

[1] National Engineering Research Center for Breeding Swine Industry, Guangdong Wens Foodstuff Co. Ltd.;State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University;

关键词: Pig;    Feed intake;    Gut microbiota;    Enterotype;    16S rRNA;    Function prediction;   

DOI  :  10.1186/s12866-018-1364-8

来源: DOAJ

【 摘 要 】

Abstract Background There are growing evidences showing that gut microbiota should play an important role in host appetite and feeding behavior. However, what kind of microbe(s) and how they affect porcine appetite remain unknown. Results In this study, 280 commercial Duroc pigs were raised in a testing station with the circadian feeding behavior records for a continuous period of 30–100 kg. We first analyzed the influences of host gender and genetics in porcine average daily feed intake (ADFI), but no significant effect was observed. We found that the Prevotella-predominant enterotype had a higher ADFI than the Treponema enterotype-like group. Furthermore, 12 out of the 18 OTUs positively associated with the ADFI were annotated to Prevotella, and Prevotella was the hub bacteria in the co-abundance network. These results suggested that Prevotella might be a keystone bacterial taxon for increasing host feed intake. However, some bacteria producing short-chain fatty acids (SCFAs) and lactic acid (e.g. Ruminococcaceae and Lactobacillus) showed negative associations with the ADFI. Predicted function capacity analysis showed that the genes for amino acid biosynthesis had significantly different enrichment between pigs with high and low ADFI. Conclusions The present study provided important information on the profound effect of gut microbiota on porcine appetite and feeding behavior. This will profit us to regulate porcine appetite through modulating the gut microbiome in the pig industry.

【 授权许可】

Unknown