Neurosecretory Protein GL Induces Fat Accumulation in Chicks

Frontiers in Endocrinology

George E. Bentley¹  Kenshiro Shikano²  Lance J. Kriegsfeld³  Megumi Furumitsu⁴  Eiko Iwakoshi-Ukena⁴  Masaki Kato⁴  Kazuyoshi Ukena⁴ 

[1] Department of Integrative Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States;Department of Neurophysiology, Faculty of Medicine, Oita University, Yufu, Japan;Department of Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States;Laboratory of Neuroendocrinology, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashihiroshima, Japan;

关键词: neurosecretory protein;    chicken;    hypothalamus;    fat accumulation;    growth;   

DOI  :  10.3389/fendo.2019.00392

来源: DOAJ

【 摘 要 】

We recently found a previously unidentified cDNA in chicken hypothalamus which encodes the precursor for neurosecretory protein GL (NPGL). A previous study showed that intracerebroventricular (i.c.v.) infusion of NPGL caused body mass gain in chicks. However, it was not clear which part(s) of the body gained mass. In the present study, we investigated which tissues increased in mass after chronic i.c.v. infusion of NPGL in chicks. We found that NPGL increased the masses of the liver, abdominal fat, and subcutaneous fat, while NPGL did not affect the masses of muscles, including pectoralis major, pectoralis minor, and biceps femoris. Oil Red O staining revealed that fat deposition had occurred in the liver. In addition, the size of the lipid droplets in the abdominal fat increased. Furthermore, we found an upregulation of lipogenesis and downregulation of lipolysis in the abdominal fat, but not in the liver. These results indicate that NPGL is involved in fat storage in chicks.

【 授权许可】

Unknown