Using pure Fucoidan and radiolabeled Fucoidan (99mTc-Fucoidan) as a new agent for inflammation diagnosis and therapy

Food Hydrocolloids for Health

Yago Amigo Pinho Jannini de Sá¹  Patrícia MachadoRodrigues e Silva²  Bianca Costa³  Maria das Graças Muller de Oliveira Henriques³  Luana Barbosa Corrêa³  Eduardo Ricci-Junior³  Elaine Cruz Rosas⁴  Edward Helal-Neto⁵  Luciana Magalhães Rebelo Alencar⁶  Rafael Loureiro Simões⁶  Fernanda Verdini Guimarães⁶  Ralph Santos-Oliveira⁷ 

[1] Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil;National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil;Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil;Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21941000, Brazil;Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, Maranhão 65080-805, Brazil;Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil;National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil;

关键词: Inflammation;    Therapy;    Radionuclide therapy;    Radiopharmacy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Inflammation is a phenomenon responsible for the perturbation of homeostasis in several levels, with many sources, such as infection, injury, and exposure to contaminants. The necessity of new products that are effective in treating inflammation processes as can selectively imaging an inflammation site is a global issue. In this study, we have evaluated the applicability of Fucoidan as a therapeutic and imaging agent. We have assessed the Fucoidan in two inflammation models for therapeutic purposes: arthritis and lungs (LPS). In the case of use as an imaging agent, we evaluated the radiolabeled Fucoidan with 99mTc in inflamed lungs (LPS). The results demonstrated that Fucoidan has a therapeutic anti-inflammatory effect, especially in the lung model (LPS). Additionally, the imaging application demonstrated that radiolabeled Fucoidan (99mTc-Fucoidan) has an important chemoattraction for inflammation sites with very high bioaccumulation, which permits to think in an imaging application.

【 授权许可】

Unknown