Evaluation of visual evoked potential as a predictive marker for diabetic neuropathy

TNOA Journal of Ophthalmic Science and Research

关键词: diabetes mellitus;    diabetic retinopathy;    neurodegeneration;    visual evoked potential;   

DOI  :  10.4103/tjosr.tjosr_83_19

来源: DOAJ

【 摘 要 】

Background: Diabetes mellitus causes neurodegeneration of retina before clinical symptoms and signs of diabetic retinopathy (DR), which may result in permanent visual loss. Hence, through neurodegenerative changes, we can predict and prevent DR well in advance. Aims and Objectives: To assess the neurodegenerative ocular morbidities among patients with diabetes before DR. Materials and Methods: This study included diabetic patients above the age of 40 years who have attended outpatient department of ophthalmology and diabetic clinic under the department of internal medicine in a tertiary care hospital in West Bengal and their age- and sex-matched control group from June 2017 to May 2018. All patients had gone through proper history taking, refraction, intraocular pressure measurement, external ocular examination, slit-lamp biomicroscopy, 90D examination, indirect ophthalmoscopy, and visual evoked potential (VEP). Results: The mean age of cases and controls was 56.87 and 57.29 years, respectively. Male and female percentage of cases and controls were 52.78 and 47.22 and 55.49 and 44.51, respectively. The percentage of Hindu and Muslim patients of cases and controls were 53.89 and 46.11 and 56.1 and 43.9, respectively. The mean P100 latency of the right and left eyes of cases was 108.61 and 107.63, whereas those of controls were 101.03 and 106.35, respectively. The mean P100 amplitude of the right and left eyes of cases was 5.68 and 5.69, whereas those of controls was 6.76 and 6.77, respectively. With respect to duration of diabetes, the mean P100 latency of the right and left eyes for <1 year, 1–2 years, and >2 years was 106.41 and 104.88, 112.19 and 112.15, and 108.38 and 107.31, respectively. With respect to duration of diabetes, the mean P100 amplitude of the right and left eyes for <1 year, 1–2 years, and 2 years was 5.42 and 5.68, 5.76 and 5.52, and 5.83 and 5.79, respectively. Conclusion: Our study shows that VEP changes occur in diabetes patients before the appearance of microaneurysm.

【 授权许可】

Unknown